LIVER CANCER AND TREATMENT !
Primary liver cancer is cancer that started in the liver. There are 5 main types. The type depends on the type of cell that the cancer started in.
If your cancer began somewhere else and then spread to the liver look at our section on secondary liver cancer.
Hepatocellular carcinoma (HCC)
Hepatocellular carcinoma is also called hepatoma or HCC. It's the most common type of primary liver cancer. Because of this, the information in the primary liver cancer section is mostly about hepatocellular cancers.
This type of liver cancer develops from the main liver cells called hepatocytes. It's more common in people who have a damaged liver from cirrhosis. Cirrhosis means scarring of the liver due to previous damage, such as from the hepatitis B or C virus or long term alcohol drinking.
Hepatocellular carcinoma is more likely to develop in men than in women and becomes more common as you get older.
Fibrolamellar carcinoma
Fibrolamellar carcinoma is a rare sub type of hepatocellular cancer (HCC).
Fibrolamellar carcinoma tends to develop in people in their 20’s or 30’s, and it’s not usually linked with cirrhosis or infection with hepatitis B or C.
The other main difference is that people with fibrolamellar carcinomas don’t usually have higher levels of alpha fetoprotein (AFP) in their blood.
Cholangiocarcinoma (bile duct cancer)
Cholangio refers to the bile ducts, so cholangiocarcinoma is cancer of the bile ducts. The bile ducts are tubes that connect the liver and gallbladder to the small bowel. The bile ducts carry bile, which is made by the liver. Bile helps to digest fats in food.
Bile duct cancer is rare. Cancer that starts in the section of ducts outside the liver is called extrahepatic cholangiocarcinoma. Cancer that starts in the section of ducts inside the liver is called intrahepatic cholangiocarcinoma. Intrahepatic cholangiocarcinoma is classed as a type of primary liver cancer, but is treated as bile
Cancer that starts in the liver (primary liver cancer) doesn't usually cause symptoms in the early stages. When you do have symptoms, they can include:
- weight loss
- yellowing of the skin and whites of the eyes (jaundice)
- itching
- feeling sick
- swollen tummy (abdomen)
- loss of appetite or feeling full after eating small amounts
- pain in your abdomen or your right shoulder
- a lump in the right side of your abdomen
If you already have a liver condition such as cirrhosis, tell your doctor if you have any new or worsening symptoms.
See your GP if you have any of these symptoms. Remember primary liver cancer is rare in the UK and these symptoms can be caused by other conditions. But it's important to get them checked by a doctor.
About these symptoms
The symptoms vary depending on where the cancer is. Some symptoms, such as itching, are caused by the jaundice.
Symptoms of liver cancer are often quite vague, such as feeling sick and loss of appetite.
Weight loss
Unexplained weight loss is a symptom of liver cancer.
Doctors define significant weight loss as losing more than 10% of your body weight. This means losing 1 stone for every 10 stone that you weigh.
See your doctor if there is no obvious reason for your weight loss.
Yellowing of the skin and whites of the eyes (jaundice)
Jaundice is the yellowing of the skin and the whites of the eyes. When you have jaundice your wee (urine) is darker than normal and your poo (bowel motion or stool) is lighter in colour. Most people who have jaundice also have itchy skin and may feel sick.
Jaundice is caused from a blockage in the bile duct or your liver not working properly.
You can get a high temperature (fever) when you have jaundice. It can be a sign of inflammation or an infection. When your temperature is high you may feel cold and shivery.
A swollen tummy (abdomen)
Liver cancer can cause swelling of the tummy (abdomen). This might be because:
- the liver gets bigger from the growing cancer, and causes swelling on the right side of your abdomen
- the cancer (or cirrhosis) increases pressure in the liver causing blood to back up in the vessels (veins). This forces fluid out of the veins into the abdomen (ascites)
The increased pressure in the veins can make them swell so they might be seen under the surface of your abdomen. Ascites can also develop when the liver isn’t making enough blood protein (albumin)
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